Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 4/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL455586 | 0.74 | RIPK1 (0.40) | RIPK1MAOBPDE5AJAK2NTRK1 | |
| SCHEMBL28670748 | 0.74 | RIPK1 (0.37) | RIPK1MAOBPDE5AJAK2NTRK1 | |
| SCHEMBL430776 | 0.71 | RIPK1 (0.47) | RIPK1MAOBPDE5AJAK2NTRK1 | |
| SCHEMBL448624 | 0.71 | RIPK1 (0.47) | RIPK1MAOBPDE5AJAK2NTRK1 | |
| SCHEMBL945868 | 0.68 | NTRK1 (0.58) | JAK2NTRK1 | |
| SCHEMBL431587 | 0.66 | HTR2A (0.35) | RIPK1MAOBMAOAIDO1 | |
| SCHEMBL433152 | 0.66 | HTR2A (0.35) | RIPK1MAOBMAOAIDO1 | |
| SCHEMBL451170 | 0.66 | HTR2A (0.35) | RIPK1MAOBMAOAIDO1 | |
| SCHEMBL4518142 | 0.64 | RIPK1 (0.41) | RIPK1MAOBPDE5AALDH1A1MAOA | |
| SCHEMBL4501581 | 0.64 | RIPK1 (0.41) | RIPK1MAOBPDE5AALDH1A1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451812-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2012-05-16 | — | — | EP | disclosed |
| WO-2011006074-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2011-01-13 | — | — | WO | disclosed |