Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 8/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL430776 | 0.79 | RIPK1 (0.47) | RIPK1MAOBMAOAPDE5AKDM4E | |
| SCHEMBL448624 | 0.79 | RIPK1 (0.47) | RIPK1MAOBMAOAPDE5AKDM4E | |
| SCHEMBL28670748 | 0.79 | RIPK1 (0.37) | RIPK1MAOBMAOAPDE5AJAK2 | |
| SCHEMBL454802 | 0.77 | RIPK1 (0.44) | RIPK1MAOBMAOAPDE5AHTR2A | |
| SCHEMBL454071 | 0.77 | RIPK1 (0.44) | RIPK1MAOBMAOAPDE5AHTR2A | |
| SCHEMBL458228 | 0.77 | RIPK1 (0.44) | RIPK1MAOBMAOAPDE5AHTR2A | |
| SCHEMBL454486 | 0.76 | RIPK1 (0.46) | RIPK1MAOBMAOAPDE5AHTR2A | |
| SCHEMBL454745 | 0.76 | RIPK1 (0.46) | RIPK1MAOBMAOAPDE5AHTR2A | |
| SCHEMBL457570 | 0.76 | RIPK1 (0.46) | RIPK1MAOBMAOAPDE5AHTR2A | |
| SCHEMBL981085 | 0.74 | RIPK1 (0.34) | RIPK1MAOBMAOAPDE5AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2614062-A1 | IMIDAZO [1, 2]PYRIDAZIN COMPOUNDS AND COMPOSITIONS AS TRK INHIBITORS | IRM LLC (BM) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012034091-A1 | IMIDAZO [1, 2] PYRIDAZIN COMPOUNDS AND COMPOSITIONS AS TRK INHIBITORS | IRM LLC (BM) | 2012-03-15 | — | — | WO | disclosed |