Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.34 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.33 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.31 |
| ▸ | GNRHR | P30968 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2856300 | 0.93 | TDO2 (0.37) | JAK2CA1CA2HMOX1 | |
| SCHEMBL2867747 | 0.84 | JAK2 (0.46) | JAK2CA1CA2 | |
| SCHEMBL2865418 | 0.83 | SRC (0.39) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL3502735 | 0.79 | JAK2 (0.54) | JAK2 | |
| SCHEMBL2858032 | 0.73 | JAK2 (0.44) | JAK2CA1CA2 | |
| SCHEMBL3499488 | 0.72 | JAK2 (0.53) | JAK2 | |
| SCHEMBL13249147 | 0.69 | ATM (0.35) | PDK1PDK2PDK3PDK4ATM | |
| SCHEMBL2868860 | 0.67 | ACSS2 (0.41) | — | |
| SCHEMBL2859344 | 0.64 | MAPT (0.43) | — | |
| SCHEMBL3500139 | 0.62 | JAK2 (0.50) | JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200612-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009035575-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2009-03-19 | — | — | WO | disclosed |