Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACSS2 | Q9NR19 | 17/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2858246 | 0.87 | MAPT (0.43) | MAPT | |
| SCHEMBL2859344 | 0.84 | MAPT (0.43) | MAPTMAPK14TP53 | |
| SCHEMBL11981748 | 0.80 | JAK2 (0.48) | ACSS2MAPK14 | |
| SCHEMBL3502963 | 0.80 | JAK2 (0.48) | ACSS2MAPK14 | |
| SCHEMBL2870379 | 0.77 | LYN (0.34) | — | |
| SCHEMBL2863267 | 0.69 | JAK2 (0.37) | TP53 | |
| SCHEMBL2867090 | 0.67 | JAK2 (0.34) | — | |
| SCHEMBL2868877 | 0.65 | MAPT (0.43) | MAPTMAPK14 | |
| SCHEMBL2872707 | 0.64 | JAK2 (0.56) | MAPT | |
| SCHEMBL5858634 | 0.64 | NR1H4 (0.55) | ACSS2TP53POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200612-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-06-30 | — | — | EP | claimed |
| WO-2009035575-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2009-03-19 | — | — | WO | claimed |
| EP-2200612-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009035575-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2009-03-19 | — | — | WO | disclosed |