Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Serotonin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A2 known ✓ | Q05940 | 1/20 | 0.76 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.54 |
| ▸ | HTR2C | P28335 | 7/20 | 0.76 |
| ▸ | HTR1A | P08908 | 6/20 | 0.76 |
| ▸ | HTR7 | P34969 | 5/20 | 0.76 |
| ▸ | TSHR | P16473 | 4/20 | 0.76 |
| ▸ | HTR1B | P28222 | 4/20 | 0.76 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.76 |
| ▸ | HTR2A | P28223 | 3/20 | 0.76 |
| ▸ | HTR2B | P41595 | 3/20 | 0.76 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.76 |
| ▸ | HTR1D | P28221 | 3/20 | 0.76 |
| ▸ | HTR5A | P47898 | 3/20 | 0.76 |
| ▸ | HTR6 | P50406 | 3/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.76 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.76 |
| ▸ | HTR1E | P28566 | 2/20 | 0.76 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.76 |
| ▸ | HTR3B | O95264 | 1/20 | 0.76 |
| ▸ | DRD1 | P21728 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Serotonin SCHEMBL28661389 | 1.00 | HTR2C (0.76) | HTR2CHTR1AHTR7TSHRHTR1B | |
| Serotonin SCHEMBL9166747 | 0.96 | HTR2C (0.74) | HTR2CHTR1AHTR7TSHRHTR1B | |
| Stearic Acid SCHEMBL8430927 | 0.93 | TRPV1 (0.66) | HTR2CHTR1AHTR7TSHRHTR1B | |
| SCHEMBL1270126 | 0.89 | NPSR1 (0.68) | HTR2CHTR1AHTR7TSHRHTR1B | |
| Serotonin SCHEMBL5833418 | 0.89 | HTR2C (0.85) | HTR2CHTR1AHTR7TSHRHTR1B | |
| Serotonin SCHEMBL28307138 | 0.89 | HTR2C (0.85) | HTR2CHTR1AHTR7TSHRHTR1B | |
| Serotonin SCHEMBL28466208 | 0.88 | HTR2C (0.83) | HTR2CHTR1AHTR7TSHRHTR1B | |
| Serotonin SCHEMBL30057954 | 0.87 | HTR2C (1.00) | HTR2CHTR1AHTR7TSHRHTR1B | |
| Serotonin SCHEMBL29349412 | 0.87 | HTR2C (1.00) | HTR2CHTR1AHTR7TSHRHTR1B | |
| Serotonin SCHEMBL1495 | 0.87 | HTR2C (1.00) | HTR2CHTR1AHTR7TSHRHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113845465-A | Method for synthesizing 5-hydroxytryptamine adipate | 河北维达康生物科技有限公司 | 2021-12-28 | — | — | CN | claimed |
| CN-113845465-A | Method for synthesizing 5-hydroxytryptamine adipate | 河北维达康生物科技有限公司 | 2021-12-28 | — | — | CN | disclosed |
| CN-113845465-A | Method for synthesizing 5-hydroxytryptamine adipate | 河北维达康生物科技有限公司 | 2021-12-28 | — | — | CN | disclosed |
| CN-113845465-A | Method for synthesizing 5-hydroxytryptamine adipate | 河北维达康生物科技有限公司 | 2021-12-28 | — | — | CN | disclosed |