Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 3/20 | 0.48 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.48 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 9/20 | 0.38 |
| ▸ | JAK1 | P23458 | 9/20 | 0.38 |
| ▸ | TYK2 | P29597 | 9/20 | 0.38 |
| ▸ | JAK3 | P52333 | 9/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | SGK1 | O00141 | 1/20 | 0.36 |
| ▸ | USP7 | Q93009 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL28687582 | 0.93 | FGFR1 (0.42) | FGFR1FGFR2HASPINJAK2JAK1 | |
| SCHEMBL28931797 | 0.88 | JAK3 (0.51) | FGFR1FGFR2JAK2JAK1TYK2 | |
| SCHEMBL20699367 | 0.85 | PIK3CD (0.47) | FGFR1FGFR2JAK2JAK1TYK2 | |
| SCHEMBL30161646 | 0.85 | PIK3CD (0.47) | FGFR1FGFR2JAK2JAK1TYK2 | |
| Trifluoroacetic Acid SCHEMBL28686997 | 0.82 | JAK3 (0.47) | FGFR1JAK2JAK1TYK2JAK3 | |
| SCHEMBL20699403 | 0.82 | JAK3 (0.49) | FGFR1FGFR2JAK2JAK1TYK2 | |
| SCHEMBL30161719 | 0.82 | JAK3 (0.49) | FGFR1FGFR2JAK2JAK1TYK2 | |
| SCHEMBL28696221 | 0.82 | TDO2 (0.36) | FGFR1FGFR2JAK2JAK1TYK2 | |
| SCHEMBL28672841 | 0.82 | FGFR1 (0.41) | FGFR1FGFR2HASPINJAK2JAK1 | |
| SCHEMBL28687763 | 0.81 | JAK3 (0.57) | JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113831326-A | Condensed heterocyclic derivative and application thereof in medicine | 四川海思科制药有限公司 | 2021-12-24 | — | — | CN | disclosed |