Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 2/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.38 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MME | P08473 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2864239 | 0.77 | USP30 (0.46) | ADRB3CYP3A4CYP2C19POLB | |
| SCHEMBL2853532 | 0.75 | ALDH1A1 (0.58) | CYP3A4CYP2C19MAPTSMN1; SMN2 | |
| SCHEMBL4433353 | 0.73 | ALDH1A1 (0.52) | ALPLSLC22A12SLC40A1MAPTSMN1; SMN2 | |
| SCHEMBL14718102 | 0.72 | SLC22A12 (0.43) | CNR2RORCALPLCASP1SLC22A12 | |
| SCHEMBL14718098 | 0.72 | SLC22A12 (0.43) | CNR2RORCALPLCASP1SLC22A12 | |
| SCHEMBL14718097 | 0.72 | SLC22A12 (0.43) | CNR2RORCALPLCASP1SLC22A12 | |
| SCHEMBL14718100 | 0.72 | SLC22A12 (0.43) | CNR2RORCALPLCASP1SLC22A12 | |
| SCHEMBL12491364 | 0.72 | SMN1; SMN2 (0.54) | ALPLSLC22A12SLC40A1CYP2C19NSD2 | |
| SCHEMBL10154346 | 0.69 | ALPL (0.52) | CNR2ALPLSLC22A12SLC40A1MAPT | |
| SCHEMBL2867340 | 0.69 | CCR1 (0.43) | CNR2RORCALPLSLC22A12SLC40A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2253328-A1 | Cycloalkyl inhibitors of potassium channel function | Bristol-Myers Squibb Company (US) | 2010-11-24 | — | — | EP | disclosed |