Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.47 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ALPL | P05186 | 1/20 | 0.46 |
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.45 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1723245 | 0.88 | MCHR1 (0.47) | ALDH1A1MAPTL3MBTL1MCHR1ADRA2A | |
| SCHEMBL23052300 | 0.84 | DRD2 (0.52) | — | |
| SCHEMBL2470085 | 0.83 | ALPL (0.42) | ALDH1A1MAPTL3MBTL1MCHR1ADRA2A | |
| SCHEMBL3027665 | 0.81 | MCHR1 (0.61) | ALDH1A1MAPTMCHR1ADRA2ANPY5R | |
| SCHEMBL27999788 | 0.77 | ALPL (0.53) | MAPTNPSR1ALPLSLC22A12SLC40A1 | |
| SCHEMBL418590 | 0.75 | ALPL (0.52) | MAPTNPSR1ALPLSLC22A12SLC40A1 | |
| SCHEMBL28312855 | 0.75 | SLC22A12 (0.54) | MAPTNPSR1ALPLSLC22A12SLC40A1 | |
| SCHEMBL8229520 | 0.75 | ALPL (0.52) | MAPTGAANPSR1ALPLSLC22A12 | |
| SCHEMBL10154346 | 0.75 | ALPL (0.52) | MAPTNPSR1ALPLSLC22A12SLC40A1 | |
| SCHEMBL3006664 | 0.75 | MCHR1 (0.66) | L3MBTL1MCHR1ADRA2ANPY5RHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137145-A2 | CYANOPYRROL SULFONAMIDES USEFUL FOR MODULATION OF THE PROGESTERONE RECEPTOR | Wyeth (US) | 2009-12-30 | — | — | EP | claimed |
| WO-2008109055-A2 | CYANOPYRROLE SULFONAMIDES USEFUL FOR MODULATION OF THE PROGESTERONE RECEPTOR | WYETH (US) | 2008-09-12 | — | — | WO | claimed |