SCHEMBL28677199

SCHEMBL28677199

NNC(=O)CCCC(Cl)c1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.47
LMNA P02545 1/20 0.46
CYP1A2 P05177 1/20 0.45
CYP3A4 P08684 1/20 0.45
CYP2D6 P10635 1/20 0.45
CYP2C19 P33261 1/20 0.45
CTSD P07339 1/20 0.43
HDAC3 O15379 3/20 0.43
HDAC4 P56524 3/20 0.43
HDAC1 Q13547 3/20 0.43
HDAC7 Q8WUI4 3/20 0.43
HDAC2 Q92769 3/20 0.43
HDAC10 Q969S8 3/20 0.43
HDAC11 Q96DB2 3/20 0.43
HDAC8 Q9BY41 3/20 0.43
HDAC6 Q9UBN7 3/20 0.43
HDAC9 Q9UKV0 3/20 0.43
HDAC5 Q9UQL6 3/20 0.43
KMT2A Q03164 1/20 0.42
IDO1 P14902 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29032349 0.90 L3MBTL1 (0.50) L3MBTL1LMNACYP1A2CYP3A4CYP2D6
SCHEMBL10571059 0.83 HDAC4 (0.62) CYP1A2CYP3A4CYP2D6HDAC3HDAC4
SCHEMBL2003510 0.81 HDAC3 (0.47) CYP1A2CYP2D6CYP2C19HDAC3HDAC4
SCHEMBL9702157 0.79 CTSD (0.50) L3MBTL1LMNACYP1A2CYP3A4CYP2D6
SCHEMBL8161664 0.76 TBXAS1 (0.42) L3MBTL1LMNACYP2D6CYP2C19HDAC3
SCHEMBL10573919 0.75 POLB (0.60) CYP3A4HDAC3HDAC4HDAC1HDAC7
3,3-Diphenylpropanoic Acid SCHEMBL29200462 0.74 L3MBTL1 (0.47) L3MBTL1LMNACYP1A2CYP3A4CYP2D6
SCHEMBL22042223 0.74 TSHR (0.50)
SCHEMBL6404252 0.74 CYP2D6 (0.46) LMNACYP1A2CYP2D6CYP2C19KMT2A
SCHEMBL10569398 0.74 EPHX2 (0.70) L3MBTL1LMNAHDAC3HDAC4HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113683629-B Substituted heteroaryl compounds, compositions and uses thereof 北京范恩柯尔生物科技有限公司 2023-07-04 CN disclosed
CN-113683629-A Substituted heteroaryl compounds, compositions and uses thereof 北京范恩柯尔生物科技有限公司 2021-11-23 CN disclosed