SCHEMBL2867840

SCHEMBL2867840

Cc1cccc2c1C([Zr](Cl)(Cl)(=C(c1ccccc1)c1ccccc1)C1c3cc(C(C)(C)C)ccc3-c3ccc(C(C)(C)C)cc31)C=C2

nearest known ligand 0.32

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.32
KCNK9 Q9NPC2 1/20 0.32
TP53 P04637 1/20 0.31
THRB P10828 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
MRGPRX4 Q96LA9 1/20 0.30
ALDH1A1 P00352 1/20 0.30
CA12 O43570 1/20 0.30
CA1 P00915 1/20 0.30
CA9 Q16790 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2862491 0.89
SCHEMBL2872271 0.89 LMNA (0.32) LMNA
SCHEMBL2857632 0.89 LMNA (0.32) LMNAALDH1A1
SCHEMBL2862478 0.88 S1PR4 (0.32) LMNASMN1; SMN2
SCHEMBL2870325 0.87 LMNA (0.33) LMNA
SCHEMBL2866685 0.87 CA12 (0.31) KCNK9CA12CA1CA9
SCHEMBL2863940 0.86 LMNA (0.31) LMNAKCNK9TP53THRBSMN1; SMN2
SCHEMBL2861483 0.86 LMNA (0.31) LMNA
SCHEMBL2862712 0.85 HSP90AA1 (0.32) LMNA
SCHEMBL2871040 0.85 KCNK3 (0.31) LMNAKCNK9SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1964860-B1 ETHYLENE POLYMER, CATALYST FOR PRODUCTION OF ETHYLENE POLYMER, AND PROCESS FOR PRODUCTION OF ETHYLENE POLYMER TOSOH CORP (JP) 2017-07-05 EP disclosed
US-7838611-B2 Ethylene polymer, catalyst for ethylene polymer production, and method for producing ethylene polymer TOSOH CORPORATION (JP) 2010-11-23 US disclosed
US-7678866-B2 Polyethylene composition and process for producing same TOSOH CORPORATION (JP) 2010-03-16 US disclosed
US-20090137755-A1 ETHYLENE POLYMER, CATALYST FOR ETHYLENE POLYMER PRODUCTION, AND METHOD FOR PRODUCING ETHYLENE POLYMER TOSOH CORPORATION (JP) 2009-05-28 US disclosed
EP-1473323-A1 Polyethylene composition and process for producing same Tosoh Corporation (JP) 2004-11-03 EP disclosed
US-20040214953-A1 Polyethylene composition and process for producing same TOSOH CORPORATION 2004-10-28 US disclosed