SCHEMBL28678690

SCHEMBL28678690

C#CC(OC(C#C)c1ccc(F)cc1)c1ccc(F)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 3/20 0.41
TDO2 P48775 2/20 0.41
ALDH1A1 P00352 1/20 0.32
LMNA P02545 1/20 0.32
ALPG P10696 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
HDAC3 O15379 1/20 0.32
HDAC4 P56524 1/20 0.32
HDAC1 Q13547 1/20 0.32
HDAC7 Q8WUI4 1/20 0.32
HDAC2 Q92769 1/20 0.32
HDAC10 Q969S8 1/20 0.32
HDAC11 Q96DB2 1/20 0.32
HDAC8 Q9BY41 1/20 0.32
HDAC6 Q9UBN7 1/20 0.32
HDAC9 Q9UKV0 1/20 0.32
HDAC5 Q9UQL6 1/20 0.32
ESR1 P03372 1/20 0.32
ESR2 Q92731 1/20 0.32
AOC3 Q16853 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6203275 0.83 IDO1 (0.54) IDO1TDO2ALDH1A1LMNAALPG
Hydrochloric Acid SCHEMBL7227150 0.81 IDO1 (0.55) IDO1TDO2ALDH1A1LMNAALPG
SCHEMBL28704077 0.77 IDO1 (0.40) IDO1TDO2ALDH1A1LMNASMN1; SMN2
SCHEMBL28689290 0.77 PYCR1 (0.39) ESR1ESR2
SCHEMBL8408252 0.77 MEN1 (0.36) ALDH1A1ESR1ESR2
SCHEMBL28684583 0.77 CES2 (0.37)
SCHEMBL28684586 0.77 PDE2A (0.41) IDO1TDO2ALDH1A1
SCHEMBL29415184 0.77 CES2 (0.37)
Hydrochloric Acid SCHEMBL27479207 0.77 IDO1 (0.37) IDO1TDO2
SCHEMBL77245 0.76 DPP4 (0.36) IDO1TDO2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109336829-B Aryl formamide compound containing 1,2, 3-triazole structure and application thereof 沈阳药科大学 2022-03-01 CN disclosed