Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28688168 | 0.88 | MAPT (0.53) | MAPTTHRBTP53GAAALDH1A1 | |
| SCHEMBL28665720 | 0.88 | MAPT (0.54) | MAPTTHRBTP53GAAALDH1A1 | |
| SCHEMBL28667847 | 0.86 | MAPT (0.56) | MAPTTHRBTP53GAAALDH1A1 | |
| SCHEMBL28665714 | 0.85 | MAPT (0.64) | MAPTTHRBTP53GAAABCG2 | |
| SCHEMBL28683437 | 0.82 | MAPT (0.55) | MAPTTHRBTP53GAALMNA | |
| SCHEMBL28661668 | 0.81 | MAPT (0.51) | MAPTTHRBTP53GAAALDH1A1 | |
| SCHEMBL28665641 | 0.81 | MAPT (0.58) | MAPTTHRBTP53GAAALDH1A1 | |
| SCHEMBL28681669 | 0.81 | MAPT (0.56) | MAPTTHRBTP53GAAALDH1A1 | |
| SCHEMBL28930626 | 0.81 | MAPT (0.68) | MAPTTHRBTP53GAAALDH1A1 | |
| SCHEMBL28670959 | 0.81 | MAPT (0.50) | MAPTTHRBTP53GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108658889-B | 1,2, 4-oxadiazole-aryl piperazine compound containing naphthalene ring and preparation method and application thereof | 贵州医科大学 | 2021-12-17 | — | — | CN | disclosed |