Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 10/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | MLYCD | O95822 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1826062 | 0.90 | HPGD (0.54) | HPGDALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL16086852 | 0.86 | HPGD (0.44) | HPGDALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL28693899 | 0.77 | HPGD (0.53) | HPGDKMT2AMEN1TSHRLMNA | |
| SCHEMBL2924871 | 0.72 | CA2 (0.52) | HPGDALDH1A1 | |
| SCHEMBL10721733 | 0.70 | HPGD (0.95) | HPGDALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL6881685 | 0.69 | HTT (0.47) | HPGDALDH1A1KMT2AMEN1TSHR | |
| SCHEMBL968638 | 0.69 | L3MBTL1 (0.50) | HPGDALDH1A1KDM4ETSHRLMNA | |
| SCHEMBL7132525 | 0.69 | HPGD (1.00) | HPGDALDH1A1KMT2AMEN1TSHR | |
| SCHEMBL969811 | 0.67 | HPGD (0.52) | HPGDALDH1A1TSHRLMNAGAA | |
| SCHEMBL3388578 | 0.67 | HPGD (0.46) | HPGDALDH1A1KDM4EKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114380799-A | COT modulators and methods of use thereof | 吉利德科学公司 | 2022-04-22 | — | — | CN | disclosed |
| CN-109879859-B | COT modulators and methods of use thereof | 吉利德科学公司 | 2022-01-25 | — | — | CN | disclosed |