Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | PPARA | Q07869 | 4/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 6/20 | 0.44 |
| ▸ | CTSS | P25774 | 4/20 | 0.44 |
| ▸ | PPARG | P37231 | 3/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | ACE | P12821 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28684647 | 1.00 | CYP1A2 (0.46) | CYP1A2CYP2C9CYP2C19HTTALDH1A1 | |
| SCHEMBL25361007 | 0.91 | KLK5 (0.47) | PPARACTSKCTSSPPARGCTSL | |
| SCHEMBL3753362 | 0.91 | KLK5 (0.47) | PPARACTSKCTSSPPARGCTSL | |
| SCHEMBL3753366 | 0.91 | KLK5 (0.47) | PPARACTSKCTSSPPARGCTSL | |
| SCHEMBL17291652 | 0.88 | PPARA (0.57) | PPARACTSKCTSSPPARGCTSL | |
| SCHEMBL20974785 | 0.88 | PPARA (0.57) | PPARACTSKCTSSPPARGCTSL | |
| SCHEMBL15448116 | 0.88 | PPARA (0.57) | PPARACTSKCTSSPPARGCTSL | |
| SCHEMBL7851771 | 0.86 | PPARA (0.43) | MAPTPPARACTSKCTSSPPARG | |
| SCHEMBL31385404 | 0.86 | PPARA (0.46) | PPARACTSKCTSSPPARGCTSL | |
| SCHEMBL31385282 | 0.85 | PPARA (0.45) | PPARACTSKCTSSPPARGCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12492210-B2 | Tricyclic compounds and their use | HUTCHISON MEDIPHARMA LIMITED (CN) | 2025-12-09 | — | — | US | disclosed |
| CN-117486888-A | Tricyclic compounds and uses thereof | 和记黄埔医药（上海）有限公司 | 2024-02-02 | — | — | CN | disclosed |
| CN-117486890-A | Tricyclic compounds and uses thereof | 和记黄埔医药（上海）有限公司 | 2024-02-02 | — | — | CN | disclosed |
| CN-113966336-B | Tricyclic compounds and uses thereof | 和记黄埔医药（上海）有限公司 | 2023-11-07 | — | — | CN | disclosed |
| US-20220315597-A1 | TRICYCLIC COMPOUNDS AND THEIR USE | HUTCHISON MEDIPHARMA LIMITED (CN) | 2022-10-06 | — | — | US | disclosed |
| EP-3980424-A1 | TRICYCLIC COMPOUNDS AND THEIR USE | Hutchison Medipharma Limited (CN) | 2022-04-13 | — | — | EP | disclosed |
| CN-113966336-A | Tricyclic compound and use thereof | 和记黄埔医药（上海）有限公司 | 2022-01-21 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220315597-A1 | TRICYCLIC COMPOUNDS AND THEIR USE | CYP2C8, CYP11B2, CYP3A7 | CYP1A2 15/4885CYP2C9 13/4885CYP2C19 8/4885 |
| US-12492210-B2 | Tricyclic compounds and their use | CYP2C8, CYP11B2, CYP3A7 | CYP1A2 15/4885CYP2C9 13/4885CYP2C19 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.