Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Perampanel. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 known ✓ | P42261 | 1/20 | 0.90 |
| ▸ | GRIA3 known ✓ | P42263 | 1/20 | 0.90 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.90 |
| ▸ | GRM5 | P41594 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Perampanel SCHEMBL2859211 | 0.96 | GRIA1 (0.86) | GRIA1GRIA3PDE4DGRM5MEN1 | |
| Perampanel SCHEMBL29718723 | 0.95 | GRIA1 (1.00) | GRIA1GRIA3PDE4DGRM5MEN1 | |
| Perampanel SCHEMBL29354621 | 0.95 | GRIA1 (1.00) | GRIA1GRIA3PDE4DGRM5MEN1 | |
| Perampanel SCHEMBL194370 | 0.95 | GRIA1 (1.00) | GRIA1GRIA3PDE4DGRM5MEN1 | |
| Perampanel SCHEMBL4214584 | 0.95 | GRIA1 (1.00) | GRIA1GRIA3PDE4DGRM5MEN1 | |
| Perampanel SCHEMBL31069847 | 0.95 | GRIA1 (1.00) | GRIA1GRIA3PDE4DGRM5MEN1 | |
| Perampanel SCHEMBL2857277 | 0.95 | GRIA1 (1.00) | GRIA1GRIA3PDE4DGRM5MEN1 | |
| Perampanel SCHEMBL2864324 | 0.94 | GRIA1 (0.83) | GRIA1GRIA3PDE4DGRM5MEN1 | |
| Perampanel SCHEMBL29363161 | 0.94 | GRIA1 (0.98) | GRIA1GRIA3PDE4DGRM5MEN1 | |
| Perampanel SCHEMBL2866904 | 0.94 | GRIA1 (0.98) | GRIA1GRIA3PDE4DGRM5MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7718807-B2 | Salt of 1,2-dihydropyridine compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-05-18 | — | — | US | claimed |
| US-20090054654-A1 | SALT OF 1,2-DIHYDROPYRIDINE COMPOUND | CATALYST PHARMACEUTICALS, INC. | 2009-02-26 | — | — | US | claimed |
| US-7718807-B2 | Salt of 1,2-dihydropyridine compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-05-18 | — | — | US | disclosed |
| US-20090054654-A1 | SALT OF 1,2-DIHYDROPYRIDINE COMPOUND | CATALYST PHARMACEUTICALS, INC. | 2009-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054654-A1 | SALT OF 1,2-DIHYDROPYRIDINE COMPOUND | SDHA, FH, SDHB | GRIA1 1884/4885GRIA3 3682/4885PDE4D 4447/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.