Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KLK7 | P49862 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | NPR3 | P17342 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7438490 | 0.79 | MEN1 (0.43) | APPLMNAKMT2AADRB2ADRB1 | |
| SCHEMBL17513198 | 0.73 | FFAR1 (0.41) | APPLMNAKMT2AADRB2ADRB1 | |
| SCHEMBL27395438 | 0.72 | APP (0.41) | APPLMNAKMT2AADRB2ADRB1 | |
| SCHEMBL13892363 | 0.72 | KMT2A (0.38) | LMNAKMT2ACTSSCTSKMEN1 | |
| SCHEMBL15268895 | 0.72 | ROCK1 (0.41) | APPADRB2ADRB1ADRB3CTSS | |
| SCHEMBL27637907 | 0.71 | APP (0.40) | APPLMNAKMT2AADRB2ADRB1 | |
| SCHEMBL14445115 | 0.70 | APP (0.42) | APPADRB2ADRB1ADRB3CTSS | |
| SCHEMBL15241731 | 0.70 | FAAH (0.57) | LMNAKMT2ACTSSCTSKFAAH | |
| SCHEMBL29169865 | 0.69 | APP (0.41) | APPLMNAKMT2AADRB2ADRB1 | |
| SCHEMBL15268669 | 0.69 | LMNA (0.44) | APPLMNAKMT2AADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113950477-A | Modulators of progranulin and methods of use thereof | 阿库达医疗公司 | 2022-01-18 | — | — | CN | disclosed |