Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KLK7 | P49862 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15268895 | 0.86 | ROCK1 (0.41) | APPADRB2ADRB1ADRB3CTSS | |
| SCHEMBL2293652 | 0.83 | MEN1 (0.55) | MEN1LMNAKMT2AMAPTTDP1 | |
| SCHEMBL14445115 | 0.83 | APP (0.42) | KCNQ2APPADRB2ADRB1ADRB3 | |
| SCHEMBL14445113 | 0.82 | HPGD (0.36) | MEN1LMNAKMT2AAPPADRB2 | |
| SCHEMBL28322525 | 0.81 | MAPT (0.42) | MEN1LMNAKMT2AKCNQ2HPGD | |
| SCHEMBL13687168 | 0.81 | ESR1 (0.50) | MEN1LMNAKMT2AKCNQ2HPGD | |
| SCHEMBL28686134 | 0.79 | APP (0.36) | MEN1LMNAKMT2AAPPADRB2 | |
| SCHEMBL11090216 | 0.79 | ALDH1A1 (0.47) | MEN1LMNAKMT2AADRB2ADRB1 | |
| SCHEMBL23003724 | 0.79 | KCNQ2 (0.47) | LMNAKCNQ2TDP1 | |
| SCHEMBL9895911 | 0.78 | KMT2A (0.48) | MEN1LMNAKMT2AADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0642338-B1 | USE OF (E)-2-(p-FLUOROPHENETHYL)-3-FLUOROALLYLAMINE IN THE TREATEMENT OF ALZHEIMER'S DISEASE | MERRELL PHARMA INC (US) | 1997-01-22 | — | — | EP | disclosed |
| EP-0720475-A1 | TRANSDERMAL DEVICE CONTAINING (E)-2-(P-FLUOROPHENETHYL)-3-FLUOROALLYLAMINE FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERRELL PHARMACEUTICALS INC. (US) | 1996-07-10 | — | — | EP | disclosed |
| WO-1995008325-A1 | TRANSDERMAL DEVICE CONTAINING (E)-2-(P-FLUOROPHENETHYL)-3-FLUOROALLYLAMINE FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERRELL PHARMACEUTICALS INC. (US) | 1995-03-30 | — | — | WO | disclosed |
| EP-0642338-A1 | USE OF (E)-2-(p-FLUOROPHENETHYL)-3-FLUOROALLYLAMINE IN THE TREATEMENT OF ALZHEIMER'S DISEASE. | MERRELL DOW PHARMA (US) | 1995-03-15 | — | — | EP | disclosed |
| WO-1993024120-A1 | USE OF (E)-2-(p-FLUOROPHENETHYL)-3-FLUOROALLYLAMINE IN THE TREATEMENT OF ALZHEIMER'S DISEASE | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-12-09 | — | — | WO | disclosed |