SCHEMBL28686702

SCHEMBL28686702

C[Si](C)(C)C#CC(c1ccccc1)c1ccccc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CACNA2D1 P54289 1/20 0.38
CACNB2 Q08289 1/20 0.38
CACNA1C Q13936 1/20 0.38
KCNH2 Q12809 1/20 0.37
ALDH1A1 P00352 3/20 0.35
GAA P10253 2/20 0.35
NPC1 O15118 1/20 0.35
POLB P06746 1/20 0.35
RAB9A P51151 1/20 0.35
MIF P14174 2/20 0.33
DPP4 P27487 2/20 0.33
F2 P00734 1/20 0.33
TSHR P16473 1/20 0.33
SLC6A2 P23975 1/20 0.33
SLC6A4 P31645 1/20 0.33
SLC6A3 Q01959 1/20 0.33
HTT P42858 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
AKR1C3 P42330 1/20 0.33
AKR1C1 Q04828 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2799259 0.78 CACNA2D1 (0.56) CACNA2D1CACNB2CACNA1CALDH1A1TSHR
SCHEMBL15449643 0.78 TRPA1 (0.48) CACNA2D1CACNB2CACNA1CGAAMIF
SCHEMBL4599196 0.78 CACNA2D1 (0.56) CACNA2D1CACNB2CACNA1CKCNH2ALDH1A1
SCHEMBL6704021 0.75 ALDH1A1 (0.37) CACNA2D1CACNB2CACNA1CALDH1A1GAA
SCHEMBL4725725 0.74 TRPA1 (0.39) CACNA2D1CACNB2CACNA1CALDH1A1TSHR
SCHEMBL8975316 0.73 KCNH2 (0.40) KCNH2ALDH1A1MIFDPP4F2
SCHEMBL17729332 0.69 KMT2A (0.53) ALDH1A1TSHRHTTKMT2A
SCHEMBL17975207 0.69 ALDH1A1 (0.37) KCNH2ALDH1A1GAATSHRSLC6A2
SCHEMBL1110900 0.69 TSHR (0.41) KCNH2DPP4F2TSHRTRPA1
SCHEMBL10728954 0.69 DPP4 (0.38) KCNH2RAB9AMIFDPP4F2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114106338-A Silicon aryne resin with p-diacetylene diphenylmethane structure and composite material and preparation method thereof 华东理工大学 2022-03-01 CN claimed
CN-114106338-A Silicon aryne resin with p-diacetylene diphenylmethane structure and composite material and preparation method thereof 华东理工大学 2022-03-01 CN disclosed