Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.61 |
| ▸ | NOS2 | P35228 | 4/20 | 0.42 |
| ▸ | ARG2 | P78540 | 4/20 | 0.40 |
| ▸ | ARG1 | P05089 | 3/20 | 0.40 |
| ▸ | NOS1 | P29475 | 3/20 | 0.40 |
| ▸ | NOS3 | P29474 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.39 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.39 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.39 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL28685610 | 1.00 | GSR (0.61) | GSRNOS2ARG2ARG1NOS1 | |
| Lysine SCHEMBL7113285 | 0.89 | GSR (0.67) | GSRNOS2ARG2ARG1NOS1 | |
| Lysine SCHEMBL7113294 | 0.89 | GSR (0.67) | GSRNOS2ARG2ARG1NOS1 | |
| Lysine SCHEMBL20530995 | 0.89 | GSR (0.67) | GSRNOS2ARG2ARG1NOS1 | |
| Lysine SCHEMBL28699455 | 0.88 | GSR (0.61) | GSRGNAI3GNAO1GNAI1 | |
| Lysine SCHEMBL29267977 | 0.88 | GSR (0.61) | GSRGNAI3GNAO1GNAI1 | |
| Lysine SCHEMBL29267982 | 0.88 | GSR (0.61) | GSRGNAI3GNAO1GNAI1 | |
| Lysine SCHEMBL28695052 | 0.88 | GSR (0.61) | GSRGNAI3GNAO1GNAI1 | |
| Lysine SCHEMBL28695050 | 0.88 | GSR (0.61) | GSRGNAI3GNAO1GNAI1 | |
| Lysine SCHEMBL28699457 | 0.88 | GSR (0.61) | GSRGNAI3GNAO1GNAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113912802-B | Ionic polyimine network material and preparation method thereof | 四川大学 | 2022-08-12 | — | — | CN | disclosed |
| CN-113912802-A | Ionic type polyimine network material and preparation method thereof | 四川大学 | 2022-01-11 | — | — | CN | disclosed |