Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | ACSS2 | Q9NR19 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | LOX | P28300 | 1/20 | 0.41 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.41 |
| ▸ | LOXL4 | Q96JB6 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28933622 | 0.88 | ACSS2 (0.59) | HTTLMNAPKMACSS2MAPT | |
| SCHEMBL28708882 | 0.88 | HTT (0.47) | HTTLMNAPKMACSS2MAPT | |
| SCHEMBL28702514 | 0.85 | ACSS2 (0.55) | HTTLMNAPKMACSS2MAPT | |
| SCHEMBL28933623 | 0.81 | HTT (0.50) | HTTLMNAPKMACSS2MAPT | |
| SCHEMBL28708842 | 0.80 | LMNA (0.75) | HTTLMNAPKMACSS2MAPT | |
| SCHEMBL28699196 | 0.80 | HTT (0.49) | HTTLMNAPKMACSS2MAPT | |
| SCHEMBL28709872 | 0.79 | HTT (0.57) | HTTLMNAPKMACSS2MAPT | |
| SCHEMBL28700508 | 0.79 | HTT (0.48) | HTTLMNAPKMACSS2MAPT | |
| SCHEMBL28709789 | 0.77 | HTT (0.58) | HTTLMNAPKMACSS2MAPT | |
| SCHEMBL22678453 | 0.77 | MAPT (0.41) | ACSS2MAPTALDH1A1KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114127049-A | ACSS2 inhibitors and methods of use thereof | 美特波米德有限公司 | 2022-03-01 | — | — | CN | disclosed |
| CN-114008025-A | ACSS2 inhibitors and methods of use thereof | 美特波米德有限公司 | 2022-02-01 | — | — | CN | disclosed |