Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 10/20 | 0.51 |
| ▸ | TMEM97 | Q5BJF2 | 7/20 | 0.51 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.47 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28931799 | 0.93 | NR1H2 (0.51) | SIGMAR1TMEM97NR1H2NR1H3NAMPT | |
| SCHEMBL28672619 | 0.85 | PDE4B (0.46) | SIGMAR1TMEM97NR1H2NR1H3CYP3A4 | |
| SCHEMBL28681451 | 0.84 | SIGMAR1 (0.46) | SIGMAR1TMEM97 | |
| SCHEMBL19211125 | 0.84 | SIGMAR1 (0.52) | SIGMAR1TMEM97NAMPTMAPT | |
| SCHEMBL28690516 | 0.79 | NR1H2 (0.48) | NR1H2NR1H3MAPT | |
| SCHEMBL2707267 | 0.79 | SIGMAR1 (0.61) | SIGMAR1TMEM97NR1H2NR1H3NAPEPLD | |
| SCHEMBL19211083 | 0.78 | SMN1; SMN2 (0.52) | SIGMAR1NAMPTMAPT | |
| SCHEMBL28681437 | 0.77 | ABCB1 (0.46) | NR1H2NR1H3NAMPTCYP3A4MAPT | |
| SCHEMBL28683481 | 0.76 | PDK1 (0.39) | SIGMAR1TMEM97NAPEPLDCYP3A4MAPT | |
| SCHEMBL28679751 | 0.76 | NR1H2 (0.52) | NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109071560-B | Thienopyridine carboxamides as ubiquitin-specific protease inhibitors | 瓦洛健康公司 | 2022-01-14 | — | — | CN | disclosed |
| CN-109071561-B | Thienopyrazine carboxamides as ubiquitin-specific protease inhibitors | 福马治疗股份有限公司 | 2022-01-14 | — | — | CN | disclosed |