Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 2/20 | 0.43 |
| ▸ | METTL3 | Q86U44 | 2/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 9/20 | 0.39 |
| ▸ | JAK2 | O60674 | 8/20 | 0.39 |
| ▸ | JAK1 | P23458 | 4/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 2/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22676717 | 0.84 | SRC (0.52) | SRCEGFRTGFBR1 | |
| SCHEMBL17495562 | 0.81 | RORC (0.46) | RORC | |
| SCHEMBL29452477 | 0.80 | RET (0.41) | PRMT5METTL3WDR77LRRK2SRC | |
| SCHEMBL17963809 | 0.78 | RORC (0.46) | RORC | |
| SCHEMBL22678034 | 0.78 | SRC (0.41) | PRMT5METTL3WDR77SRCEGFR | |
| SCHEMBL28685316 | 0.76 | DYRK1A (0.44) | LRRK2SRCEGFRJAK3JAK2 | |
| SCHEMBL26109077 | 0.75 | RET (0.41) | PRMT5METTL3WDR77LRRK2SRC | |
| SCHEMBL30582581 | 0.75 | RET (0.41) | PRMT5METTL3WDR77LRRK2SRC | |
| SCHEMBL23536300 | 0.72 | PROKR1 (0.39) | — | |
| SCHEMBL28700136 | 0.72 | LRRK2 (0.43) | LRRK2SRCEGFRJAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114126620-A | FGFR inhibitors and methods of use thereof | 传达治疗有限公司 | 2022-03-01 | — | — | CN | disclosed |