Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 10/20 | 0.41 |
| ▸ | EGFR | P00533 | 4/20 | 0.41 |
| ▸ | FGR | P09769 | 1/20 | 0.41 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.41 |
| ▸ | TXK | P42681 | 1/20 | 0.41 |
| ▸ | FRK | P42685 | 1/20 | 0.41 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 2/20 | 0.40 |
| ▸ | TEK | Q02763 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 5/20 | 0.40 |
| ▸ | ABL2 | P42684 | 3/20 | 0.40 |
| ▸ | METTL3 | Q86U44 | 2/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.37 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29452477 | 0.80 | RET (0.41) | SRCLCKTEKABL1METTL3 | |
| SCHEMBL26109077 | 0.80 | RET (0.41) | SRCLCKABL1METTL3PRMT5 | |
| SCHEMBL30582581 | 0.80 | RET (0.41) | SRCLCKABL1METTL3PRMT5 | |
| SCHEMBL28690889 | 0.78 | PRMT5 (0.43) | SRCEGFRMETTL3PRMT5WDR77 | |
| SCHEMBL28844238 | 0.75 | RORC (0.39) | — | |
| SCHEMBL29407719 | 0.73 | DYRK1A (0.49) | SRCEGFRFGREPHA1TXK | |
| SCHEMBL22676700 | 0.73 | DYRK1A (0.49) | SRCEGFRFGREPHA1TXK | |
| SCHEMBL22676717 | 0.73 | SRC (0.52) | SRCEGFRABL1ABL2RET | |
| SCHEMBL10261381 | 0.69 | FGR (0.57) | SRCEGFRFGREPHA1TXK | |
| SCHEMBL463027 | 0.69 | ADK (0.48) | SRCEGFRFRKPTK6LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020231990-A1 | FGFR INHIBITORS AND METHODS OF USE THEREOF | RELAY THERAPEUTICS, INC. (US) | 2020-11-19 | — | — | WO | disclosed |