Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 3/20 | 0.39 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PI4KA | P42356 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | LOX | P28300 | 1/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30253592 | 1.00 | IKBKB (0.39) | IKBKBSIRT6CHEK2KMT2ATHRB | |
| SCHEMBL28698965 | 0.87 | SIRT6 (0.33) | IKBKBSIRT6 | |
| SCHEMBL28644566 | 0.87 | SIRT6 (0.36) | IKBKBSIRT6KMT2ACA9MEN1 | |
| SCHEMBL30253497 | 0.87 | SIRT6 (0.33) | IKBKBSIRT6 | |
| SCHEMBL28707295 | 0.86 | CHEK2 (0.38) | IKBKBSIRT6CHEK2PIK3CDPIK3CA | |
| SCHEMBL30253749 | 0.86 | CHEK2 (0.38) | IKBKBSIRT6CHEK2PIK3CDPIK3CA | |
| SCHEMBL28639557 | 0.86 | LMNA (0.36) | SIRT6KMT2AMEN1 | |
| SCHEMBL28652992 | 0.84 | MAPT (0.41) | KMT2AMEN1 | |
| SCHEMBL28685074 | 0.83 | MAPT (0.39) | IKBKBSIRT6MKNK1MKNK2NNMT | |
| SCHEMBL28708619 | 0.83 | HTT (0.43) | SIRT6KMT2ATHRBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113336713-A | Preparation method of alkoxy pyrazine derivative and alkoxy pyrazine derivative | 中国人民解放军军事科学院军事医学研究院 | 2021-09-03 | — | — | CN | claimed |
| CN-113336713-B | Preparation method of alkoxy pyrazine derivative and alkoxy pyrazine derivative | 中国人民解放军军事科学院军事医学研究院 | 2023-03-17 | — | — | CN | disclosed |
| CN-113336713-A | Preparation method of alkoxy pyrazine derivative and alkoxy pyrazine derivative | 中国人民解放军军事科学院军事医学研究院 | 2021-09-03 | — | — | CN | disclosed |