Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.61 |
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29428157 | 1.00 | KDM4E (0.61) | KDM4EMAPTHSD17B10SMN1; SMN2ALDH1A1 | |
| SCHEMBL28694312 | 0.82 | KDM4E (0.56) | KDM4EMAPTHSD17B10SMN1; SMN2ALDH1A1 | |
| SCHEMBL29428154 | 0.82 | KDM4E (0.56) | KDM4EMAPTHSD17B10SMN1; SMN2ALDH1A1 | |
| SCHEMBL28932333 | 0.80 | ALDH1A1 (0.68) | KDM4EMAPTSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL29428166 | 0.76 | MAPT (0.54) | KDM4EMAPTHSD17B10SMN1; SMN2ALDH1A1 | |
| SCHEMBL28699030 | 0.76 | MAPT (0.54) | KDM4EMAPTHSD17B10SMN1; SMN2ALDH1A1 | |
| SCHEMBL17241565 | 0.76 | KDM4E (0.81) | KDM4EMAPTHSD17B10SMN1; SMN2ALDH1A1 | |
| SCHEMBL7325383 | 0.75 | MTNR1A (0.68) | KDM4EMAPTHSD17B10SMN1; SMN2ALDH1A1 | |
| SCHEMBL25723962 | 0.75 | ALDH1A1 (0.56) | KDM4EHSD17B10SMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL28685040 | 0.74 | MAPT (0.54) | KDM4EMAPTHSD17B10SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109776434-B | 3-benzyl-6-acylamino-2, 4- (1H,3H) -quinazoline diketone derivative and synthesis method and application thereof | 中南大学 | 2022-01-28 | — | — | CN | disclosed |