Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | BACE1 | P56817 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TOP1 | P11387 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.47 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28699030 | 1.00 | MAPT (0.54) | MAPTTP53BACE1KDM4ESMN1; SMN2 | |
| SCHEMBL28683077 | 0.93 | MAPT (0.57) | MAPTTP53BACE1KDM4ESMN1; SMN2 | |
| SCHEMBL29428151 | 0.85 | MAPT (0.54) | MAPTTP53BACE1KDM4ESMN1; SMN2 | |
| SCHEMBL28685040 | 0.85 | MAPT (0.54) | MAPTTP53BACE1KDM4ESMN1; SMN2 | |
| SCHEMBL28692022 | 0.81 | SETD7 (0.64) | MAPTKMT2AALDH1A1MEN1PTGS2 | |
| SCHEMBL29428168 | 0.81 | SETD7 (0.64) | MAPTKMT2AALDH1A1MEN1PTGS2 | |
| SCHEMBL28692020 | 0.76 | KDM4E (0.61) | MAPTTP53BACE1KDM4ESMN1; SMN2 | |
| SCHEMBL29428157 | 0.76 | KDM4E (0.61) | MAPTTP53BACE1KDM4ESMN1; SMN2 | |
| SCHEMBL28694312 | 0.73 | KDM4E (0.56) | MAPTTP53BACE1KDM4ESMN1; SMN2 | |
| SCHEMBL29428154 | 0.73 | KDM4E (0.56) | MAPTTP53BACE1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109776434-B | 3-benzyl-6-acylamino-2, 4- (1H,3H) -quinazoline diketone derivative and synthesis method and application thereof | 中南大学 | 2022-01-28 | — | — | CN | disclosed |