Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 3/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.47 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TYR | P14679 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15462344 | 0.88 | TYR (0.46) | TTRPTGS1TRPA1CACNA1CKDM4E | |
| SCHEMBL4517427 | 0.86 | ALDH1A1 (0.46) | TTRPTGS1TRPA1CACNA1CKDM4E | |
| SCHEMBL7545091 | 0.84 | TRPA1 (0.48) | PTGS1TRPA1CACNA1CKDM4ETYR | |
| SCHEMBL2736378 | 0.81 | NTRK1 (0.43) | TTRPTGS1TRPA1CACNA1C | |
| SCHEMBL11584107 | 0.81 | PTGS1 (0.39) | TTRPTGS1 | |
| SCHEMBL14470905 | 0.79 | HTR2A (0.42) | TTRPTGS1 | |
| SCHEMBL15472268 | 0.79 | TTR (0.55) | TTRALDH1A1HTT | |
| SCHEMBL5992552 | 0.79 | ALDH1A1 (0.50) | TTRALDH1A1ALOX12HTT | |
| SCHEMBL2736379 | 0.79 | FFAR1 (0.49) | TTR | |
| SCHEMBL6061209 | 0.79 | HPGD (0.46) | TYRALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140243401-A1 | METHODS OF SCREENING COMPOUNDS THAT ARE CYTOTOXIC TO TUMOR CELLS AND METHODS OF TREATING TUMOR CELLS USING SUCH COMPOUND | THE JOHNS HOPKINS UNIVERSITY (US) | 2014-08-28 | — | — | US | disclosed |
| EP-2655706-A2 | METHODS OF SCREENING COMPOUNDS THAT ARE CYTOTOXIC TO TUMOR CELLS AND METHODS OF TREATING TUMOR CELLS USING SUCH COMPOUND | Ronnett, Gabrielle (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012071562-A2 | METHODS OF SCREENING COMPOUNDS THAT ARE CYTOTOXIC TO TUMOR CELLS AND METHODS OF TREATING TUMOR CELLS USING SUCH COMPOUND | RONNETT GABRIELLE (US) | 2012-05-31 | — | — | WO | disclosed |
| US-7687547-B2 | Diphenyl ether antimicrobial compounds | RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2010-03-30 | — | — | US | disclosed |
| US-20060041025-A1 | 5-Alkyl (4-26 carbon atoms)-2-phenoxyphenols; enoyl reductase enzyme inhibitor; drug resistance; side-effect reduction; nicrobiocides; carriers | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2006-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060041025-A1 | 5-Alkyl (4-26 carbon atoms)-2-phenoxyphenols; enoyl reductase enzyme inhibitor; drug resistance; side-effect reduction; nicrobiocides; carriers | CBR1, CBR3, FAR1 | TTR 3309/4885PTGS1 1651/4885TRPA1 3767/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.