⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8831747 | 0.83 | — | — | |
| SCHEMBL15693977 | 0.83 | SLC6A1 (0.31) | — | |
| SCHEMBL28296227 | 0.80 | — | — | |
| SCHEMBL23802787 | 0.80 | ITGB3 (0.50) | — | |
| SCHEMBL23802737 | 0.80 | ITGB3 (0.50) | — | |
| SCHEMBL25154289 | 0.80 | SLC6A1 (0.50) | — | |
| SCHEMBL21315847 | 0.80 | SLC6A1 (0.50) | — | |
| SCHEMBL2917738 | 0.80 | SLC6A1 (0.50) | — | |
| SCHEMBL10884869 | 0.78 | LMNA (0.32) | — | |
| SCHEMBL22022942 | 0.78 | LMNA (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000061144-A1 | METHOD AND MEANS FOR PREVENTING, TREATING, AND DIAGNOSING CARDIOVASCULAR COMPLICATIONS IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA | HEDNER JAN (SE) | 2000-10-19 | — | — | WO | claimed |
| US-7662845-B2 | 2,5-Dioxoimidazolidin-4-yl acetamides and analogues as inhibitors of metalloproteinase MMP12 | ASTRAZENECA AB (SE) | 2010-02-16 | — | — | US | disclosed |
| US-7354940-B2 | 2,5-dioxoimidazolidin-4-yl acetamines and analogues as inhibitors of metalloproteinase mmp12 | ASTRAZENECA AB (SE) | 2008-04-08 | — | — | US | disclosed |
| EP-1542977-B1 | 2,5-DIOXOIMIDAZOLIDIN-4-YL ACETAMIDES AND ANALOGUES AS INHIBITORS OF METALLOPROTEINASE MMP12. | ASTRAZENECA AB (SE) | 2006-12-20 | — | — | EP | disclosed |
| US-20060276524-A1 | 2,5-Dioxoimidazolidin-4-yl acetamides and analogues as inhibitors of metalloproteinase MMP12 | ASTRAZENECA AB, A SWEDEN CORPORATION | 2006-12-07 | — | — | US | disclosed |
| US-20050245586-A1 | 2,5-Dioxoimidazolidin-4-yl acetamides and analogues as inhibitors of metalloproteinase mmp12 | ASTRAZENECA AB (SE) | 2005-11-03 | — | — | US | disclosed |
| EP-1542977-A1 | 2,5-DIOXOIMIDAZOLIDIN-4-YL ACETAMIDES AND ANALOGUES AS INHIBITORS OF METALLOPROTEINASE MMP12. | AstraZeneca AB (SE) | 2005-06-22 | — | — | EP | disclosed |
| WO-2004020415-A1 | 2,5-DIOXOIMIDAZOLIDIN-4-YL ACETAMIDES AND ANALOGUES AS INHIBITORS OF METALLOPROTEINASE MMP12. | ASTRAZENECA AB (SE) | 2004-03-11 | — | — | WO | disclosed |
| WO-2000061144-A1 | METHOD AND MEANS FOR PREVENTING, TREATING, AND DIAGNOSING CARDIOVASCULAR COMPLICATIONS IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA | HEDNER JAN (SE) | 2000-10-19 | — | — | WO | disclosed |