Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.60 |
| ▸ | CIT | O14578 | 1/20 | 0.60 |
| ▸ | GAK | O14976 | 1/20 | 0.60 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.60 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.60 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.60 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.60 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.60 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.60 |
| ▸ | STK17B | O94768 | 1/20 | 0.60 |
| ▸ | STK10 | O94804 | 1/20 | 0.60 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.60 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.60 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.60 |
| ▸ | ABL1 | P00519 | 1/20 | 0.60 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.60 |
| ▸ | LCK | P06239 | 1/20 | 0.60 |
| ▸ | LYN | P07948 | 1/20 | 0.60 |
| ▸ | RET | P07949 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4787463 | 0.87 | EGFR (0.70) | EGFRCITGAKEPHB6RIPK2 | |
| SCHEMBL28696327 | 0.82 | EPHA2 (0.67) | EGFRCITGAKEPHB6ABCC4 | |
| SCHEMBL29577645 | 0.80 | FBP1 (0.78) | EGFRERBB2FLT4KDREPHB4 | |
| SCHEMBL29577315 | 0.80 | FBP1 (0.78) | EGFRERBB2FLT4KDREPHB4 | |
| SCHEMBL4535987 | 0.80 | KDR (0.78) | EGFRCITGAKEPHB6ABCC4 | |
| SCHEMBL7867197 | 0.79 | FLT1 (0.66) | EGFRFLT4KDREPHB4 | |
| SCHEMBL15217656 | 0.79 | EGFR (0.90) | EGFRERBB2FLT4KDREPHB4 | |
| SCHEMBL28387145 | 0.79 | EPHA2 (0.72) | EGFRCITGAKEPHB6ABCC4 | |
| SCHEMBL29577833 | 0.78 | EGFR (0.92) | EGFRCITGAKEPHB6ABCC4 | |
| SCHEMBL28713534 | 0.78 | EGFR (0.92) | EGFRCITGAKEPHB6ABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108069913-B | Bis (morpholinylalkoxy) quinazoline derivative and application thereof in anti-tumor aspect | 陕西师范大学 | 2022-03-01 | — | — | CN | disclosed |