Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD known ✓ | O00329 | 3/20 | 0.32 |
| ▸ | ACVRL1 | P37023 | 6/20 | 0.34 |
| ▸ | TYRO3 | Q06418 | 4/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.31 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphoric Acid SCHEMBL28694996 | 0.82 | POLRMT (0.33) | ACVRL1PIK3CDRIPK1 | |
| Phosphoric Acid SCHEMBL16701315 | 0.80 | PIK3CD (0.36) | ACVRL1PIK3CDTNK2 | |
| Phosphoric Acid SCHEMBL21082020 | 0.78 | PIK3CD (0.37) | ACVRL1PIK3CDTNK2 | |
| SCHEMBL16698811 | 0.72 | ACVRL1 (0.39) | ACVRL1PIK3CD | |
| Phosphoric Acid SCHEMBL20742040 | 0.72 | POLRMT (0.38) | ACVRL1PIK3CDRIPK1TNK2 | |
| SCHEMBL16708594 | 0.71 | POLRMT (0.45) | — | |
| SCHEMBL10101499 | 0.70 | ACVRL1 (0.38) | ACVRL1PIK3CD | |
| SCHEMBL20756113 | 0.69 | ACVRL1 (0.36) | ACVRL1PIK3CDTNK2 | |
| Phosphoric Acid SCHEMBL16701720 | 0.69 | PIK3CD (0.33) | ACVRL1PIK3CDRIPK1 | |
| SCHEMBL23959932 | 0.69 | ACVRL1 (0.39) | ACVRL1TYRO3PIK3CDTNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114085243-A | Pyrrolo [1,2-f ] [1,2,4] triazines useful for the treatment of respiratory syncytial virus infection | 吉利德科学公司 | 2022-02-25 | — | — | CN | disclosed |
| CN-110003215-B | Pyrrolo [1,2-f ] [1,2,4] triazines useful for the treatment of respiratory syncytial virus infection | 吉利德科学公司 | 2021-12-17 | — | — | CN | disclosed |