SCHEMBL28705474

SCHEMBL28705474

Cn1nc(C(N)=O)c(C(=O)c2ccc(Cl)cc2Cl)c1OCc1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.47
RAB9A P51151 3/20 0.47
PTGER1 P34995 5/20 0.44
CNR1 P21554 4/20 0.44
ALDH1A1 P00352 3/20 0.41
NPSR1 Q6W5P4 1/20 0.41
CYP1A2 P05177 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
KDM4E B2RXH2 2/20 0.40
HTT P42858 2/20 0.40
TDP1 Q9NUW8 1/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
HSD17B10 Q99714 1/20 0.40
MAPT P10636 2/20 0.39
PKM P14618 1/20 0.39
HPGD P15428 1/20 0.38
MDM2 Q00987 1/20 0.38
GPR55 Q9Y2T6 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11117488 0.86 NPC1 (0.47) NPC1RAB9APTGER1CNR1ALDH1A1
SCHEMBL148140 0.79 NPC1 (0.48) NPC1RAB9APTGER1CNR1ALDH1A1
SCHEMBL27970564 0.77 NPC1 (0.48) NPC1RAB9APTGER1CNR1ALDH1A1
SCHEMBL10751205 0.76 SMN1; SMN2 (0.45) NPC1RAB9AALDH1A1NPSR1CYP1A2
SCHEMBL7200151 0.73 MAPT (0.42) NPC1RAB9AALDH1A1NPSR1CYP1A2
SCHEMBL27542976 0.73 SMN1; SMN2 (0.47) NPC1RAB9AALDH1A1NPSR1CYP1A2
SCHEMBL10673937 0.73 NPC1 (0.46) NPC1RAB9APTGER1CNR1ALDH1A1
SCHEMBL10668454 0.73 RAB9A (0.46) NPC1RAB9APTGER1CNR1ALDH1A1
SCHEMBL4889275 0.72 ABCB1 (0.45) NPC1RAB9AALDH1A1NPSR1CYP1A2
SCHEMBL54326 0.72 ABCB1 (0.45) NPC1RAB9AALDH1A1NPSR1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114158553-A Novel pesticide preparation and preparation method thereof 南开沧州渤海新区绿色化工研究有限公司 2022-03-11 CN disclosed