Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 8/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8042099 | 0.93 | SIGMAR1 (0.53) | CXCR4SIGMAR1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL25493322 | 0.90 | CXCR4 (0.58) | CXCR4SIGMAR1SMN1; SMN2HRH3HRH2 | |
| SCHEMBL10196944 | 0.82 | PSMB1 (0.41) | SIGMAR1SMN1; SMN2MEN1KMT2ACHRM2 | |
| SCHEMBL8068190 | 0.82 | PSMB1 (0.44) | SIGMAR1SMN1; SMN2MEN1KMT2ACHRM2 | |
| SCHEMBL29317405 | 0.82 | SMN1; SMN2 (0.46) | CXCR4SIGMAR1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL12605242 | 0.82 | SMN1; SMN2 (0.46) | CXCR4SIGMAR1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL12865877 | 0.81 | SIGMAR1 (0.46) | SIGMAR1SMN1; SMN2MEN1KMT2ACHRM5 | |
| SCHEMBL2621583 | 0.81 | SMN1; SMN2 (0.49) | CXCR4SIGMAR1SMN1; SMN2HRH3HRH2 | |
| SCHEMBL1698707 | 0.81 | PSMB1 (0.47) | SMN1; SMN2HRH3MEN1KMT2ACHRM2 | |
| SCHEMBL9917381 | 0.81 | PSMB1 (0.47) | SMN1; SMN2HRH3MEN1KMT2ACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109563092-B | 2-phenylimidazo [4,5-B ] pyridin-7-amine derivatives useful as inhibitors of the activity of the mammalian tyrosine kinase ROR1 | 坎塞拉有限公司 | 2021-09-14 | — | — | CN | disclosed |