Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | BCR | P11274 | 2/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.32 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28712257 | 0.88 | L3MBTL1 (0.42) | PTPN11L3MBTL1CA1CA2MEN1 | |
| SCHEMBL720829 | 0.80 | TGFBR1 (0.41) | PTPN11L3MBTL1CA1CA2MEN1 | |
| SCHEMBL29607743 | 0.78 | PTPN11 (0.45) | PTPN11L3MBTL1CA1CA2MEN1 | |
| SCHEMBL7910236 | 0.78 | PTPN11 (0.40) | PTPN11L3MBTL1CA1CA2MEN1 | |
| SCHEMBL16186634 | 0.77 | L3MBTL1 (0.39) | PTPN11L3MBTL1MEN1KMT2APIM1 | |
| SCHEMBL29608973 | 0.77 | PTPN11 (0.45) | PTPN11L3MBTL1MEN1KMT2AENPP3 | |
| SCHEMBL26620863 | 0.77 | L3MBTL1 (0.39) | PTPN11L3MBTL1MEN1KMT2AALDH1A1 | |
| SCHEMBL30641868 | 0.77 | L3MBTL1 (0.39) | PTPN11L3MBTL1MEN1KMT2AALDH1A1 | |
| SCHEMBL29609087 | 0.76 | L3MBTL1 (0.42) | PTPN11L3MBTL1CA1CA2MEN1 | |
| SCHEMBL721584 | 0.76 | L3MBTL1 (0.42) | PTPN11L3MBTL1CA1CA2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115073474-A | Pyrrolo [2,3-b ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2022-09-20 | — | — | CN | disclosed |
| CN-115028639-A | Pyrrolo [2,3-b ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2022-09-09 | — | — | CN | disclosed |
| CN-114096536-A | Pyrrolo [2,3-b ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2022-02-25 | — | — | CN | disclosed |