Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.53 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1620776 | 0.90 | DRD2 (0.55) | DRD2CACNA1HTDP1SIGMAR1ALDH1A1 | |
| SCHEMBL28210559 | 0.88 | DRD2 (0.52) | DRD2CACNA1HTDP1SIGMAR1CD274 | |
| SCHEMBL29290724 | 0.84 | DRD2 (0.56) | DRD2CACNA1HTDP1SIGMAR1CD274 | |
| SCHEMBL31301242 | 0.81 | DRD2 (0.63) | DRD2CACNA1HTDP1SIGMAR1CD274 | |
| SCHEMBL24172673 | 0.79 | DRD2 (0.56) | DRD2CACNA1HTDP1SIGMAR1CD274 | |
| SCHEMBL31301250 | 0.79 | DRD2 (0.56) | DRD2CACNA1HTDP1SIGMAR1CD274 | |
| SCHEMBL4024516 | 0.79 | DRD2 (0.56) | DRD2CACNA1HTDP1MEN1GAA | |
| SCHEMBL13135942 | 0.79 | NPSR1 (0.41) | DRD2 | |
| SCHEMBL7220892 | 0.77 | DRD2 (0.55) | DRD2CACNA1HTDP1ALDH1A1MEN1 | |
| SCHEMBL13202614 | 0.77 | DRD2 (0.59) | DRD2CACNA1HTDP1SIGMAR1CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7795267-B2 | Bicyclic piperazine compound having TGR23 antagonistic activity | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-14 | — | — | US | disclosed |
| US-20070072865-A1 | Bicyclic piperazine compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-03-29 | — | — | US | disclosed |
| EP-1661898-A1 | BICYCLIC PIPERAZINE COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2006-05-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070072865-A1 | Bicyclic piperazine compound and use thereof | GPR3, FFAR3, LPAR3 | DRD2 1250/4885CACNA1H 1996/4885TDP1 4728/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.