Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | MAOB | P27338 | 15/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | ATM | Q13315 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | MIF | P14174 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 3-Coumaranone SCHEMBL69412 | 0.86 | PKM (0.56) | PKMTSHRMAOBMAPTATM | |
| 3-Coumaranone SCHEMBL29420742 | 0.86 | PKM (0.56) | PKMTSHRMAOBMAPTATM | |
| SCHEMBL2929432 | 0.83 | PKM (0.52) | PKMTSHRMAOBMAPTATM | |
| SCHEMBL86392 | 0.81 | MAPT (0.67) | PKMTSHRMAOBMAPTSMN1; SMN2 | |
| SCHEMBL29375440 | 0.81 | MAPT (0.67) | PKMTSHRMAOBMAPTSMN1; SMN2 | |
| SCHEMBL11584003 | 0.79 | PKM (0.59) | PKMTSHRMAOBSMN1; SMN2MIF | |
| SCHEMBL3553528 | 0.79 | PKM (0.59) | PKMTSHRMAOBMAPTATM | |
| 3-Coumaranone SCHEMBL28237724 | 0.78 | MAPT (0.51) | PKMTSHRMAOBMAPTATM | |
| SCHEMBL6966321 | 0.77 | PKM (1.00) | PKMTSHRMAOBMAPTATM | |
| 3-Coumaranone SCHEMBL28237723 | 0.76 | MAPT (0.47) | PKMTSHRMAOBMAPTATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116660543-A | Diagnostic and prognostic markers for nonalcoholic fatty liver disease and uses thereof | 中国人民解放军陆军军医大学第一附属医院 | 2023-08-29 | — | — | CN | claimed |
| CN-115181112-B | Synthesis and anti-tumor application of 6-bromo-cycloicaritin chromane 3, 4-diketone derivative | 遵义医科大学 | 2023-07-14 | — | — | CN | claimed |
| CN-115181112-A | Synthesis of 6-bromocyclo-icaritin chromane 3, 4-diketone derivative and anti-tumor application thereof | 遵义医科大学 | 2022-10-14 | — | — | CN | claimed |
| CN-115181112-B | Synthesis and anti-tumor application of 6-bromo-cycloicaritin chromane 3, 4-diketone derivative | 遵义医科大学 | 2023-07-14 | — | — | CN | disclosed |
| CN-115181112-B | Synthesis and anti-tumor application of 6-bromo-cycloicaritin chromane 3, 4-diketone derivative | 遵义医科大学 | 2023-07-14 | — | — | CN | disclosed |
| CN-115181112-A | Synthesis of 6-bromocyclo-icaritin chromane 3, 4-diketone derivative and anti-tumor application thereof | 遵义医科大学 | 2022-10-14 | — | — | CN | disclosed |
| CN-114163384-A | Method for synthesizing polysubstituted 5-acyl nicotinonitrile | 温州医科大学 | 2022-03-11 | — | — | CN | disclosed |