Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | MAOB | P27338 | 16/20 | 0.53 |
| ▸ | MIF | P14174 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 2/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10196642 | 0.83 | PKM (0.45) | PKMTSHRMAOBMIFMEN1 | |
| SCHEMBL15395751 | 0.79 | PKM (0.42) | PKMTSHRMAOBMIFMEN1 | |
| SCHEMBL28709151 | 0.79 | PKM (0.63) | PKMTSHRMAOBMIFMEN1 | |
| SCHEMBL29375440 | 0.78 | MAPT (0.67) | PKMTSHRMAOBKMT2ATDP1 | |
| SCHEMBL86392 | 0.78 | MAPT (0.67) | PKMTSHRMAOBKMT2ATDP1 | |
| SCHEMBL3553595 | 0.74 | MAOB (0.57) | MAOBMEN1KMT2ATDP1MAPT | |
| SCHEMBL3557966 | 0.74 | APP (0.57) | PKMTSHRTDP1MAPTTP53 | |
| SCHEMBL10977113 | 0.74 | METAP1 (0.53) | TSHRMAOBMEN1KMT2ATDP1 | |
| SCHEMBL6966321 | 0.74 | PKM (1.00) | PKMTSHRMAOBMIFMEN1 | |
| 3-Coumaranone SCHEMBL69412 | 0.74 | PKM (0.56) | PKMTSHRMAOBMIFMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-60016983-A | — | — | None | — | — | JP | disclosed |
| US-7642283-B2 | modulating the activity of the mitochrondrial permeability transition pore complex comprising exposing the complex to a compound such as 6-bromo-3-methylene-chroman-4-one | HOFFMANN-LA ROCHE INC. (US) | 2010-01-05 | — | — | US | disclosed |
| US-7642283-B2 | modulating the activity of the mitochrondrial permeability transition pore complex comprising exposing the complex to a compound such as 6-bromo-3-methylene-chroman-4-one | HOFFMANN-LA ROCHE INC. (US) | 2010-01-05 | — | — | US | disclosed |
| EP-1468995-B1 | MPTP affinity labels | HOFFMANN LA ROCHE (CH) | 2008-05-14 | — | — | EP | disclosed |
| US-20060252822-A1 | Mitochrondrial permeability transition pore affinity labels and modulators | CESURA ANDREA | 2006-11-09 | — | — | US | disclosed |
| US-7101917-B2 | Mitochrondrial permeability transition pore affinity labels and modulators | HOFFMANN-LA ROCHE INC. (US) | 2006-09-05 | — | — | US | disclosed |
| EP-1468995-A1 | MPTP affinity labels | F. HOFFMANN-LA ROCHE AG (CH) | 2004-10-20 | — | — | EP | disclosed |
| JP-S6016983-A | 3-METHYLENE-4-CHROMANONE DERIVATIVE | DAICEL CHEM IND LTD | 1985-01-28 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060252822-A1 | Mitochrondrial permeability transition pore affinity labels and modulators | MCU, ATP5PB, MFN2 | PKM 776/4885TSHR 4156/4885MAOB 1048/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.