Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 7/20 | 0.35 |
| ▸ | MME | P08473 | 1/20 | 0.33 |
| ▸ | ECE1 | P42892 | 1/20 | 0.32 |
| ▸ | AKT2 | P31751 | 3/20 | 0.32 |
| ▸ | AKT3 | Q9Y243 | 3/20 | 0.32 |
| ▸ | AKT1S1 | Q96B36 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | AXL | P30530 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.31 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.31 |
| ▸ | PRKACA | P17612 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | GSK3A | P49840 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.31 |
| ▸ | PRKX | P51817 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2876778 | 0.90 | AKT1 (0.41) | AKT1ECE1AKT2AKT3AKT1S1 | |
| SCHEMBL2879028 | 0.82 | AKT1 (0.36) | AKT1MMEECE1AKT2AKT3 | |
| SCHEMBL2876397 | 0.82 | AKT1 (0.38) | AKT1MMEECE1AKT2AKT3 | |
| SCHEMBL2876511 | 0.78 | AKT1 (0.35) | AKT1AKT2AKT3GSK3BROCK1 | |
| SCHEMBL2876171 | 0.77 | CDC42BPB (0.41) | ROCK2ROCK1 | |
| SCHEMBL2877177 | 0.77 | ROCK2 (0.41) | ROCK2PRKACAROCK1 | |
| SCHEMBL2876595 | 0.77 | CDC42BPB (0.34) | ROCK2ROCK1 | |
| SCHEMBL2875905 | 0.75 | ROCK2 (0.42) | ROCK2ROCK1 | |
| SCHEMBL2873623 | 0.75 | NPC1 (0.42) | TP53ROCK2ROCK1 | |
| SCHEMBL2876892 | 0.75 | ROCK2 (0.43) | TP53ROCK2PRKACAMAPK1ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2002836-B1 | Cyclocondensed azaindoles active as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL (IT) | 2010-10-20 | — | — | EP | disclosed |
| EP-2002836-A1 | Cyclocondensed azaindoles active as kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2008-12-17 | — | — | EP | disclosed |