Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 6/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.42 |
| ▸ | GPR88 | Q9GZN0 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 2/20 | 0.37 |
| ▸ | SNCA | P37840 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.34 |
| ▸ | CDC42BPB | Q9Y5S2 | 2/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2877177 | 0.94 | ROCK2 (0.41) | ROCK2ROCK1GPR88AURKA | |
| SCHEMBL2876892 | 0.91 | ROCK2 (0.43) | ROCK2ROCK1GPR88AURKA | |
| SCHEMBL2876221 | 0.87 | AKT1 (0.43) | ROCK2ROCK1DYRK1ADYRK1B | |
| SCHEMBL2876760 | 0.85 | ROCK2 (0.44) | ROCK2ROCK1GPR88AURKASNCA | |
| SCHEMBL2878625 | 0.84 | ROCK2 (0.44) | ROCK2ROCK1GPR88AURKASNCA | |
| SCHEMBL2881447 | 0.78 | ROCK2 (0.41) | ROCK2ROCK1GPR88AURKADYRK1A | |
| SCHEMBL2876778 | 0.77 | AKT1 (0.41) | ROCK2ROCK1EGFRMAPK14 | |
| SCHEMBL2876992 | 0.76 | ROCK2 (0.41) | ROCK2ROCK1GPR88AURKADYRK1A | |
| SCHEMBL2870470 | 0.76 | ROCK2 (0.43) | ROCK2ROCK1GPR88AURKA | |
| SCHEMBL2876171 | 0.76 | CDC42BPB (0.41) | ROCK2ROCK1CDC42BPB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2002836-B1 | Cyclocondensed azaindoles active as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL (IT) | 2010-10-20 | — | — | EP | claimed |
| EP-2002836-A1 | Cyclocondensed azaindoles active as kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2008-12-17 | — | — | EP | claimed |
| EP-2002836-B1 | Cyclocondensed azaindoles active as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL (IT) | 2010-10-20 | — | — | EP | disclosed |