SCHEMBL28709277

SCHEMBL28709277

CN(C)CCNCC(N)=O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 1/20 0.48
CYP2C19 P33261 1/20 0.48
MAOA P21397 2/20 0.47
MAOB P27338 2/20 0.47
ANPEP P15144 1/20 0.44
PRMT3 O60678 1/20 0.39
CARM1 Q86X55 1/20 0.39
PRMT6 Q96LA8 1/20 0.39
PRMT1 Q99873 1/20 0.39
PRMT8 Q9NR22 1/20 0.39
PAOX Q6QHF9 1/20 0.37
DNM1 Q05193 1/20 0.36
ALDH1A1 P00352 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
KDM4E B2RXH2 1/20 0.35
CA1 P00915 2/20 0.34
CA2 P00918 2/20 0.34
CA12 O43570 1/20 0.34
CA9 Q16790 1/20 0.34
TOP2A P11388 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4602531 0.87 MAOA (0.53) CYP2C9CYP2C19MAOAMAOBPAOX
Hydrochloric Acid SCHEMBL4913278 0.85 MAOA (0.52) CYP2C9CYP2C19MAOAMAOBPAOX
SCHEMBL23936912 0.80 CYP2C9 (0.52) CYP2C9CYP2C19ANPEPPRMT3CARM1
SCHEMBL27293107 0.79 PAOX (0.47) CYP2C9CYP2C19ANPEPPRMT3CARM1
SCHEMBL2507441 0.79 CYP2C9 (0.44) CYP2C9CYP2C19ANPEPPRMT3CARM1
SCHEMBL20914942 0.78 MAOA (0.44) CYP2C19MAOAMAOBPAOXALDH1A1
SCHEMBL7887973 0.78 PRMT3 (0.58) CYP2C9CYP2C19MAOAMAOBANPEP
SCHEMBL27293082 0.77 CYP2C9 (0.43) CYP2C9CYP2C19ANPEPPRMT3CARM1
SCHEMBL5233047 0.77 MAOA (0.61) CYP2C9CYP2C19MAOAMAOBALDH1A1
SCHEMBL1844564 0.76 PRMT3 (0.42) CYP2C9CYP2C19ANPEPPRMT3CARM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112107568-B Diaryl amide compound and application thereof 北京龙嘉博创医药科技有限公司 2022-03-25 CN claimed
EP-4288416-A2 SMALL MOLECULE INHIBITORS OF GRP78 AND USES THEREOF The Regents Of The University Of Michigan (US) 2023-12-13 EP disclosed
WO-2022169834-A2 SMALL MOLECULE INHIBITORS OF GRP78 AND USES THEREOF THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2022-08-11 WO disclosed