Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.40 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.40 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28709234 | 0.88 | MAPT (0.47) | SMN1; SMN2MAPTHPGDMAPK1MEN1 | |
| SCHEMBL16140804 | 0.78 | MAPT (0.50) | MAPTHPGDKAT6AKMT2AALDH1A1 | |
| SCHEMBL28709251 | 0.77 | KAT6A (0.49) | SMN1; SMN2MAPTHPGDKAT6AMAPK1 | |
| SCHEMBL9468482 | 0.75 | MAPT (0.62) | SMN1; SMN2MAPTHPGDMAPK1MEN1 | |
| SCHEMBL25624042 | 0.73 | MAPT (0.44) | SMN1; SMN2MAPTHPGDKAT6AMAPK1 | |
| SCHEMBL11702794 | 0.72 | POLB (0.54) | SMN1; SMN2MAPTMAPK1MEN1KMT2A | |
| SCHEMBL18289071 | 0.72 | GAA (0.62) | SMN1; SMN2MAPTHPGDMAPK1MEN1 | |
| SCHEMBL10126717 | 0.71 | MTNR1B (0.67) | SMN1; SMN2HPGDKMT2AALDH1A1GAA | |
| SCHEMBL16793988 | 0.71 | SMN1; SMN2 (0.52) | SMN1; SMN2MAPTHPGDMEN1KMT2A | |
| SCHEMBL28690119 | 0.70 | MAPT (0.47) | SMN1; SMN2MAPTHPGDKAT6AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113354635-B | Pyrrolidine integrin regulator and application thereof | 清药同创(北京)药物研发中心有限公司 | 2023-04-18 | — | — | CN | disclosed |
| CN-113354635-A | Pyrrolidine integrin regulator and application thereof | 清药同创(北京)药物研发中心有限公司 | 2021-09-07 | — | — | CN | disclosed |