Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.40 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.40 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.40 |
| ▸ | MPO | P05164 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28050451 | 0.85 | LMNA (0.54) | MAPTPOLBSMN1; SMN2RXFP1L3MBTL1 | |
| SCHEMBL2616607 | 0.77 | SMN1; SMN2 (0.52) | MAPTPOLBSMN1; SMN2RXFP1L3MBTL1 | |
| SCHEMBL11841355 | 0.75 | MAPT (0.53) | MAPTPOLBSMN1; SMN2RXFP1L3MBTL1 | |
| SCHEMBL20335031 | 0.75 | LMNA (0.65) | MAPTPOLBSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL24036729 | 0.74 | MAPT (0.42) | MAPTPOLBSMN1; SMN2RXFP1L3MBTL1 | |
| SCHEMBL16140804 | 0.74 | MAPT (0.50) | MAPTL3MBTL1TDP1ALDH1A1HPGD | |
| SCHEMBL8338087 | 0.73 | ALDH1A1 (0.69) | MAPTPOLBSMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL28709251 | 0.73 | KAT6A (0.49) | MAPTSMN1; SMN2L3MBTL1TDP1ALDH1A1 | |
| SCHEMBL16140868 | 0.72 | L3MBTL1 (0.48) | MAPTPOLBSMN1; SMN2RXFP1L3MBTL1 | |
| SCHEMBL28709234 | 0.72 | MAPT (0.47) | MAPTSMN1; SMN2L3MBTL1TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113354635-B | Pyrrolidine integrin regulator and application thereof | 清药同创(北京)药物研发中心有限公司 | 2023-04-18 | — | — | CN | disclosed |
| CN-113354635-A | Pyrrolidine integrin regulator and application thereof | 清药同创(北京)药物研发中心有限公司 | 2021-09-07 | — | — | CN | disclosed |