SCHEMBL16140804

SCHEMBL16140804

COC(=O)Cc1cccc(-n2nc(C)cc2C)c1

nearest known ligand 0.50

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.50
L3MBTL1 Q9Y468 3/20 0.50
TDP1 Q9NUW8 1/20 0.50
SLC7A5 Q01650 1/20 0.47
HPGD P15428 2/20 0.46
KMT2A Q03164 1/20 0.46
MPO P05164 1/20 0.44
ALDH1A1 P00352 2/20 0.44
NAMPT P43490 1/20 0.43
KAT6A Q92794 1/20 0.43
KLK6 Q92876 1/20 0.42
CTSG P08311 1/20 0.42
CMA1 P23946 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16140868 0.87 L3MBTL1 (0.48) MAPTL3MBTL1TDP1HPGDKMT2A
SCHEMBL16115868 0.85 L3MBTL1 (0.53) MAPTL3MBTL1TDP1KMT2AMPO
SCHEMBL19902885 0.82 KMT2A (0.54) MAPTL3MBTL1TDP1HPGDKMT2A
SCHEMBL28709251 0.81 KAT6A (0.49) MAPTL3MBTL1TDP1HPGDKMT2A
SCHEMBL28709234 0.80 MAPT (0.47) MAPTL3MBTL1TDP1HPGDKMT2A
SCHEMBL30474518 0.79 KMT2A (0.55) MAPTL3MBTL1TDP1HPGDKMT2A
SCHEMBL28699689 0.79 KMT2A (0.55) MAPTL3MBTL1TDP1HPGDKMT2A
SCHEMBL28709403 0.78 SMN1; SMN2 (0.43) MAPTL3MBTL1TDP1HPGDKMT2A
SCHEMBL17518823 0.77 MPO (0.51) MAPTL3MBTL1TDP1KMT2AMPO
SCHEMBL25624042 0.77 MAPT (0.44) MAPTL3MBTL1TDP1HPGDALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10450312-B2 Naphthyridine derivatives useful as alpha-V-beta-6 integrin antagonists GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2019-10-22 US disclosed
US-10450312-B2 Naphthyridine derivatives useful as alpha-V-beta-6 integrin antagonists GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2019-10-22 US disclosed
US-20180291022-A1 NAPHTHYRIDINE DERIVATIVES USEFUL AS ALPHA-V-BETA-6 INTEGRIN ANTAGONISTS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2018-10-11 US disclosed
US-10023568-B2 Naphthyridine derivatives useful as αvβ6 integrin antagonists GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2018-07-17 US disclosed
US-10023568-B2 Naphthyridine derivatives useful as αvβ6 integrin antagonists GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2018-07-17 US disclosed
US-10023568-B2 Naphthyridine derivatives useful as αvβ6 integrin antagonists GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2018-07-17 US disclosed
EP-2989100-B1 NAPHTHYRIDINE DERIVATIVES USEFUL AS ALPHA-V-BETA-6 INTEGRIN ANTAGONISTS GLAXOSMITHKLINE IP DEV LTD (GB) 2018-02-28 EP disclosed
EP-2989100-B1 NAPHTHYRIDINE DERIVATIVES USEFUL AS ALPHA-V-BETA-6 INTEGRIN ANTAGONISTS GLAXOSMITHKLINE IP DEV LTD (GB) 2018-02-28 EP disclosed
US-20160280705-A1 NAPHTHYRIDINE DERIVATIVES USEFUL AS ALPHA-V-BETA-6 INTEGRIN ANTAGONISTS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2016-09-29 US disclosed
US-20160280705-A1 NAPHTHYRIDINE DERIVATIVES USEFUL AS ALPHA-V-BETA-6 INTEGRIN ANTAGONISTS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2016-09-29 US disclosed
US-20160280705-A1 NAPHTHYRIDINE DERIVATIVES USEFUL AS ALPHA-V-BETA-6 INTEGRIN ANTAGONISTS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2016-09-29 US disclosed
CN-105189499-B naphthyridine derivatives useful as avbeta6 integrin antagonists 葛兰素史克知识产权开发有限公司 2016-09-28 CN disclosed
CN-105189499-A Can be used as alphavβ6Naphthyridine derivatives of integrin antagonists GLAXOSMITHKLINE IP DEV CO LTD 2015-12-23 CN disclosed
WO-2014154725-A1 NAPHTHYRIDINE DERIVATIVES USEFUL AS ALPHA-V-BETA-6 INTEGRIN ANTAGONISTS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2014-10-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160280705-A1 NAPHTHYRIDINE DERIVATIVES USEFUL AS ALPHA-V-BETA-6 INTEGRIN ANTAGONISTS ITGB6, ITGA6, ITGB1 MAPT 4413/4885L3MBTL1 1856/4885TDP1 3903/4885
US-10450312-B2 Naphthyridine derivatives useful as alpha-V-beta-6 integrin antagonists ITGB6, ITGA6, ITGB1 MAPT 4413/4885L3MBTL1 1856/4885TDP1 3903/4885
US-20180291022-A1 NAPHTHYRIDINE DERIVATIVES USEFUL AS ALPHA-V-BETA-6 INTEGRIN ANTAGONISTS ITGB6, ITGA6, ITGB1 MAPT 4413/4885L3MBTL1 1856/4885TDP1 3903/4885
US-10023568-B2 Naphthyridine derivatives useful as αvβ6 integrin antagonists ITGB6, ITGA6, ITGB3 MAPT 4049/4885L3MBTL1 2812/4885TDP1 4180/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.