SCHEMBL28715744

SCHEMBL28715744

CC(C)CCn1cccc1C(=O)CCc1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.46
PKM P14618 1/20 0.46
GRM2 Q14416 3/20 0.44
NPC1 O15118 2/20 0.43
RAB9A P51151 2/20 0.43
ALDH1A1 P00352 1/20 0.41
KEAP1 Q14145 1/20 0.40
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
HPGD P15428 1/20 0.39
TSHR P16473 1/20 0.38
GAA P10253 1/20 0.38
MAPT P10636 1/20 0.38
SLC5A1 P13866 1/20 0.38
SLC5A2 P31639 1/20 0.38
FFAR1 O14842 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28716486 0.85 NPC1 (0.46) GRM2NPC1RAB9AALDH1A1KEAP1
SCHEMBL28703134 0.82 HPGD (0.46) NPC1RAB9AALDH1A1KEAP1HPGD
SCHEMBL28713377 0.81 ALDH1A1 (0.47) NPC1RAB9AALDH1A1KEAP1KMT2A
SCHEMBL28715746 0.81 HPGD (0.48) NPC1RAB9AALDH1A1KEAP1MEN1
SCHEMBL28715739 0.80 CNR2 (0.51) LMNANPC1RAB9AALDH1A1KEAP1
SCHEMBL28713425 0.78 NPC1 (0.61) PKMNPC1RAB9AALDH1A1KEAP1
SCHEMBL29020286 0.77 NPC1 (0.48) LMNAGRM2NPC1RAB9AALDH1A1
SCHEMBL28703124 0.76 HTT (0.44) LMNAGRM2NPC1RAB9AALDH1A1
SCHEMBL6823635 0.76 LMNA (0.46) LMNAGRM2ALDH1A1KEAP1MEN1
SCHEMBL9772729 0.75 NPC1 (0.41) PKMNPC1RAB9AALDH1A1KEAP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114213307-A Preparation method of N-alkyl substituted pyrrolidone compound 河南农业大学 2022-03-22 CN disclosed