Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29038554 | 0.87 | LMNA (0.42) | LMNAMAP3K14KDM4EHTTMAPT | |
| SCHEMBL28703124 | 0.86 | HTT (0.44) | LMNAHTTMAPTALDH1A1GRM2 | |
| SCHEMBL29225360 | 0.82 | LMNA (0.40) | LMNAKDM4EHTTMAPTALDH1A1 | |
| SCHEMBL4611671 | 0.81 | MLYCD (0.40) | HTTALDH1A1GRM2CYP2D6 | |
| SCHEMBL29102668 | 0.80 | LMNA (0.50) | LMNAMAP3K14KDM4EHTTMAPT | |
| SCHEMBL27611348 | 0.80 | LMNA (0.53) | LMNAMAP3K14KDM4EMAPTALDH1A1 | |
| SCHEMBL27840672 | 0.77 | LMNA (0.47) | LMNAMAP3K14KDM4EMAPTPOLB | |
| SCHEMBL28740014 | 0.77 | CNR2 (0.40) | LMNAKDM4EHTTMAPTALDH1A1 | |
| SCHEMBL28715744 | 0.76 | LMNA (0.46) | LMNAMAPTALDH1A1GRM2MEN1 | |
| SCHEMBL4427821 | 0.76 | LMNA (0.53) | LMNAMAP3K14KDM4EMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1467969-A2 | DNA MINOR GROOVE BINDING COMPOUNDS | The University of Strathclyde (GB) | 2004-10-20 | — | — | EP | disclosed |
| WO-2003059881-A2 | DNA MINOR GROOVE BINDING COMPOUNDS | UNIVERSITY OF STRATHCLYDE (GB) | 2003-07-24 | — | — | WO | disclosed |