Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 4/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29557855 | 1.00 | SYK (0.44) | SYKTHRBAURKAL3MBTL1TSHR | |
| SCHEMBL28720668 | 0.84 | ALDH1A1 (0.48) | SYKL3MBTL1MAPTMAPK1SMN1; SMN2 | |
| SCHEMBL29558137 | 0.84 | ALDH1A1 (0.48) | SYKL3MBTL1MAPTMAPK1SMN1; SMN2 | |
| SCHEMBL25416754 | 0.79 | PPARG (0.47) | AURKAL3MBTL1MEN1MAPTKMT2A | |
| SCHEMBL29557791 | 0.79 | PPARG (0.47) | AURKAL3MBTL1MEN1MAPTKMT2A | |
| SCHEMBL23461740 | 0.74 | SLC2A1 (0.57) | SYKAURKAMAPTMAPK1KMT2A | |
| SCHEMBL15395341 | 0.73 | SYK (0.61) | SYK | |
| SCHEMBL16743228 | 0.72 | SYK (0.74) | SYK | |
| SCHEMBL18283748 | 0.70 | RAB9A (0.41) | SYKL3MBTL1MEN1MAPTMAPK1 | |
| SCHEMBL16764284 | 0.69 | KDR (0.47) | SYKL3MBTL1TSHRMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114315796-B | Compounds used as HPK1 kinase inhibitor, preparation method and application thereof | 中国药科大学 | 2024-03-26 | — | — | CN | disclosed |
| CN-114315796-A | Compound used as HPK1 kinase inhibitor and preparation method and application thereof | 中国药科大学 | 2022-04-12 | — | — | CN | disclosed |