Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 8/20 | 0.46 |
| ▸ | GAA | P10253 | 4/20 | 0.46 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | SYK | P43405 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28720668 | 1.00 | ALDH1A1 (0.48) | ALDH1A1MAPTSMN1; SMN2L3MBTL1GAA | |
| SCHEMBL28717567 | 0.84 | SYK (0.44) | MAPTSMN1; SMN2L3MBTL1GAAKDM4E | |
| SCHEMBL29557855 | 0.84 | SYK (0.44) | MAPTSMN1; SMN2L3MBTL1GAAKDM4E | |
| SCHEMBL24587281 | 0.81 | ALDH1A1 (0.48) | ALDH1A1MAPTSMN1; SMN2GAATDP1 | |
| SCHEMBL28717580 | 0.81 | ILK (0.53) | ALDH1A1MAPTSMN1; SMN2GAAKDM4E | |
| SCHEMBL29557846 | 0.81 | ILK (0.53) | ALDH1A1MAPTSMN1; SMN2GAAKDM4E | |
| SCHEMBL15395338 | 0.78 | ALDH1A1 (0.52) | ALDH1A1MAPTSMN1; SMN2GAATDP1 | |
| SCHEMBL15910674 | 0.77 | MAPT (0.53) | ALDH1A1MAPTSMN1; SMN2GAANPSR1 | |
| SCHEMBL15395623 | 0.75 | ALDH1A1 (0.52) | ALDH1A1MAPTSMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL18283767 | 0.75 | SYK (0.53) | ALDH1A1MAPTSMN1; SMN2L3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114315796-B | Compounds used as HPK1 kinase inhibitor, preparation method and application thereof | 中国药科大学 | 2024-03-26 | — | — | CN | disclosed |
| CN-114315796-A | Compound used as HPK1 kinase inhibitor and preparation method and application thereof | 中国药科大学 | 2022-04-12 | — | — | CN | disclosed |