Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LGMN | Q99538 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29433685 | 1.00 | TSHR (0.41) | TSHRUSP2MAPTHTTNPSR1 | |
| SCHEMBL28719350 | 0.89 | TSHR (0.40) | TSHRUSP2MAPTHTTNPSR1 | |
| SCHEMBL29433687 | 0.89 | TSHR (0.40) | TSHRUSP2MAPTHTTNPSR1 | |
| SCHEMBL29433692 | 0.89 | DGAT1 (0.35) | USP2MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL28708076 | 0.89 | DGAT1 (0.35) | USP2MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL29433673 | 0.77 | MAPT (0.43) | TSHRMAPTHTTNPSR1ALDH1A1 | |
| SCHEMBL28718593 | 0.77 | MAPT (0.43) | TSHRMAPTHTTNPSR1ALDH1A1 | |
| SCHEMBL28707411 | 0.77 | KDM4E (0.35) | USP2MAPTHTTALDH1A1MEN1 | |
| SCHEMBL29433684 | 0.77 | KDM4E (0.35) | USP2MAPTHTTALDH1A1MEN1 | |
| SCHEMBL22907105 | 0.72 | HTR6 (0.39) | USP2MAPTNPSR1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114163444-B | Chimeric compound for androgen receptor protein targeted degradation, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2023-07-14 | — | — | CN | disclosed |
| CN-114163444-A | Chimeric compound for targeted degradation of androgen receptor protein, preparation method thereof and application thereof in medicine | 江苏恒瑞医药股份有限公司 | 2022-03-11 | — | — | CN | disclosed |