Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MTHFD2 | P13995 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | MMP12 | P39900 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28707411 | 1.00 | KDM4E (0.35) | KDM4EALDH1A1L3MBTL1HPGDDGAT1 | |
| SCHEMBL29433687 | 0.88 | TSHR (0.40) | ALDH1A1MAPTMEN1KMT2AHTT | |
| SCHEMBL28719350 | 0.88 | TSHR (0.40) | ALDH1A1MAPTMEN1KMT2AHTT | |
| SCHEMBL28708076 | 0.86 | DGAT1 (0.35) | KDM4EALDH1A1L3MBTL1HPGDDGAT1 | |
| SCHEMBL29433692 | 0.86 | DGAT1 (0.35) | KDM4EALDH1A1L3MBTL1HPGDDGAT1 | |
| SCHEMBL28719360 | 0.77 | TSHR (0.41) | KDM4EALDH1A1MAPTLMNAMEN1 | |
| SCHEMBL29433685 | 0.77 | TSHR (0.41) | KDM4EALDH1A1MAPTLMNAMEN1 | |
| SCHEMBL28716306 | 0.76 | MAPT (0.46) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL29433670 | 0.76 | MAPT (0.46) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL7135104 | 0.71 | USP2 (0.63) | KDM4EALDH1A1MAPTLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114163444-B | Chimeric compound for androgen receptor protein targeted degradation, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2023-07-14 | — | — | CN | disclosed |
| CN-114163444-A | Chimeric compound for targeted degradation of androgen receptor protein, preparation method thereof and application thereof in medicine | 江苏恒瑞医药股份有限公司 | 2022-03-11 | — | — | CN | disclosed |