Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | FTO | Q9C0B1 | 7/20 | 0.54 |
| ▸ | ALKBH5 | Q6P6C2 | 5/20 | 0.54 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.54 |
| ▸ | KDM5A | P29375 | 2/20 | 0.54 |
| ▸ | KDM5C | P41229 | 2/20 | 0.54 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.54 |
| ▸ | KDM6B | O15054 | 1/20 | 0.54 |
| ▸ | TET3 | O43151 | 1/20 | 0.54 |
| ▸ | KDM4A | O75164 | 1/20 | 0.54 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | ASPH | Q12797 | 1/20 | 0.54 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.54 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.54 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.54 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.54 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.54 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2877411 | 0.91 | KDM4E (0.72) | KDM4EFTOALKBH5KDM4DKDM5A | |
| SCHEMBL13383595 | 0.84 | KDM4E (0.84) | KDM4EKDM4DKDM5AKDM5CKDM5B | |
| SCHEMBL12999520 | 0.82 | ITGB3 (0.61) | KDM4EFTOALKBH5KDM4DKDM5A | |
| SCHEMBL2786137 | 0.79 | KDM4E (0.72) | KDM4EFTOALKBH5KDM4DKDM5A | |
| SCHEMBL2714869 | 0.79 | FTO (0.61) | KDM4EFTOALKBH5KDM4DKDM5A | |
| SCHEMBL29831092 | 0.79 | FTO (0.61) | KDM4EFTOALKBH5KDM4DKDM5A | |
| SCHEMBL2871803 | 0.78 | FTO (0.46) | KDM4EFTOALKBH5KDM4DKDM5A | |
| SCHEMBL9561544 | 0.78 | POLB (0.51) | KDM4EALDH1A1MAPTITGB3ITGA2B | |
| SCHEMBL15286469 | 0.77 | KDM4D (0.76) | KDM4EFTOALKBH5KDM4DKDM5A | |
| SCHEMBL14904965 | 0.76 | KMT2A (0.50) | KDM4CSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010043866-A2 | HISTONE LYSINE DEMETHYLASE INHIBITORS | ISIS INNOVATION LIMITED (GB) | 2010-04-22 | — | — | WO | disclosed |
| WO-2010043866-A2 | HISTONE LYSINE DEMETHYLASE INHIBITORS | ISIS INNOVATION LIMITED (GB) | 2010-04-22 | — | — | WO | disclosed |