Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29141374 | 0.85 | POLB (0.40) | POLBMAPTCRBNALDH1A1LMNA | |
| SCHEMBL2979600 | 0.84 | MAPT (0.54) | POLBMAPTALDH1A1MAPK1LMNA | |
| SCHEMBL25712719 | 0.84 | TSHR (0.49) | POLBMAPTCRBNALDH1A1MAPK1 | |
| SCHEMBL20568475 | 0.81 | ADRB1 (0.42) | POLBMAPTLMNAKMT2AMEN1 | |
| SCHEMBL29141362 | 0.80 | VCAM1 (0.53) | POLBMAPTCRBNALDH1A1LMNA | |
| SCHEMBL30668867 | 0.80 | VCAM1 (0.53) | POLBMAPTCRBNALDH1A1LMNA | |
| SCHEMBL4717711 | 0.80 | SIRT6 (0.59) | POLBMAPTALDH1A1MAPK1LMNA | |
| SCHEMBL1172041 | 0.80 | POLB (0.51) | POLBMAPTALDH1A1MAPK1KMT2A | |
| Hydrochloric Acid SCHEMBL3258109 | 0.79 | ADRB1 (0.58) | POLBMAPTALDH1A1MAPK1LMNA | |
| SCHEMBL20557324 | 0.79 | MAPT (0.57) | MAPTALDH1A1LMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116903589-A | KIF18A inhibitor and application thereof | 武汉人福创新药物研发中心有限公司 | 2023-10-20 | — | — | CN | disclosed |
| CN-114302880-A | KIF18A inhibitors | 美国安进公司 | 2022-04-08 | — | — | CN | disclosed |